Home / News / Targeting Epigenetic Proteins to Prevent Breast Cancer

Targeting Epigenetic Proteins to Prevent Breast Cancer

Targeting Epigenetic Proteins to Prevent Breast Cancer

ITN Targeting Epigenetic Proteins to Prevent Breast Cancer

Breast cancer can occur in both women and men, and arises from the proliferation of abnormal cells. Mammary glands contain two types of cells, basal and luminal, which are formed from specialized stem or progenitor cells. The sex hormone, progesterone, can surge and induce these cells to increase mammary gland formation during pregnancy or menstruation. Epigenetic proteins can trigger stem cell proliferation in response to the increased levels of progesterone. Unfortunately, progesterone has been linked to the development of breast cancer. The number of progenitor cells is often higher in women carrying BRCA1 mutations and other genes that increase the risk of developing cancer. At this time, there are no standard preventative strategies targeting stem and progenitor cells for women at high risk of cancer.

A recent report suggests epigenetic proteins promote the proliferation of mammary gland stem cells in response to progesterone. Researchers isolated cells from the mammary glands of mice and examined the effects of exposure to progesterone. Protein levels were quantified, which indicated upregulation of epigenetic regulatory proteins that can modify chromosomes. Multiple epigenetic inhibitors that inhibited the proliferation of mammary gland progenitor cells, including FDA approved drugs, were tested. One drug, decitabine, that inhibits DNA methyltransferase enzymes, was found to reduce tumor development in cancer-prone rodents. Furthermore, progenitor cells from BRCA1 mutation patients were shown to be vulnerable to epigenetic inhibitors. Targeted drug inhibition of epigenetic proteins could prevent the development of breast cancer in women with a high risk of the disease.

For more information: http://jcb.rupress.org/content/early/2018/06/18/jcb.201804042

Enzo Life Sciences provides a wide variety of products for your Epigenetics and Cancer research needs. Our platforms provide a wide range of small molecules, antibodies, and proteins. Our FLUOR DE LYS® HDAC & Sirtuin assay platform has freed researchers from cumbersome protocols for screening HDAC & Sirtuin activity. Our high-quality chemiluminescent, fluorescent, and colorimetric assays deliver more high-quality hits, and are backed by a broad panel of characterized inhibitors and PTM-specific antibodies for ubiquitinylation, sumoylation, methylation, acetylation, and phosphorylation. Enzo offers the SCREEN-WELL® Cancer Library, a collection of 275 compounds that can be used for screening and assay development. All of the compounds in our SCREEN-WELL® FDA v. 2.0 Approved Drug Library have known and well-characterized bioactivity, safety and bioavailability – properties which could dramatically accelerate drug development and optimization.


Search with axxora.com

Pay off Axxora

Enzo Life Sciences, Inc., is organized to lead in the development, production, marketing, and sale of innovative life science research reagents worldwide. Now incorporating the skills, experience, and products of ALEXIS Biochemicals, acquired in 2007, BIOMOL International, acquired in 2008, and Assay Designs, acquired in 2009, Enzo Life Sciences provides over 25 years of business experience in the supply of research kits, biochemicals and biologicals “Enabling Discovery in Life Science™”.

Enzo Life Sciences offers a comprehensive panel of innovative life science reagents. Antibodiesenzymes & proteinssmall molecule inhibitorsproduct libraries, and ELISA and other assay kits are available for research in CancerCell DeathEpigeneticsGenomicsImmunologyNeuroscienceSignal Transduction, and Ubiquitin & Proteasomes.

Enzo Life Sciences offers a wide range of custom services. Our innovative & experienced technical staff acquired extensive know-how over the last 20 years of business in custom production and brings professional project management skills to fulfill your needs on time and to specification. Our brand new state-of-the-art laboratories guarantee production of your life science product at the highest level.

Services offered:

  • Custom Assay development
  • Custom Peptide Synthesis
  • Custom Antibody Production
  • Custom Protein Expression
  • Custom Chemical Synthesis
  • Custom-labeled FISH Probes