DNA repair processes are critical mediators of p53-dependent tumor suppression
p53, a tumor suppressor gene, is one of the most important genes in human cancer. p53 regulates responses to various stressors and is known to prevent cancer development. It is unclear as to which of the cellular processes activated by p53 are critical for suppressing tumor function. Many cancers, including colon and pancreatic, are a result of p53 mutations. Scientists have now identified a group of genes that function in the DNA repair process that are critical to p53 tumor suppressor function.
In a recent report, shRNA/CRISPR library screens were used to demonstrate that p53 can activate many diverse cellular responses. Over 300 genes that are regulated by p53 were examined. Coordination of DNA repair appears to be the most important process activated by p53 for tumor suppression. DNA repair genes including MLH1 are essential for p53’s ability to suppress tumor development. Further investigation of the genes that function in the DNA repair process could lead to more effective cancer treatments and to the identification of patients with an increased risk of developing cancer. Earlier diagnosis and more targeted cancer treatments could also be attainable.
For more information: https://www.nature.com/articles/s41591-018-0043-5
Enzo offers a wide variety of products for your Cancer and Immunology research. Our platform provides a range of small molecules, antibodies, and proteins. In particular, we offer PD-1, PD-L1, LAG-3, and MEGACD40L proteins for your research needs. The SCREEN-WELL® Cancer Library is a collection of 275 compounds that can be used for cancer inhibitor screening and assay development. Enzo offers a p53 ELISA Kit for the quantitative determination of human p53 in cell culture supernatants, human serum, plasma and other biological fluids.
Search with axxora.com
Enzo Life Sciences, Inc., is organized to lead in the development, production, marketing, and sale of innovative life science research reagents worldwide. Now incorporating the skills, experience, and products of ALEXIS Biochemicals, acquired in 2007, BIOMOL International, acquired in 2008, and Assay Designs, acquired in 2009, Enzo Life Sciences provides over 25 years of business experience in the supply of research kits, biochemicals and biologicals “Enabling Discovery in Life Science™”.
Enzo Life Sciences offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes & proteins, small molecule inhibitors, product libraries, and ELISA and other assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes.
Enzo Life Sciences offers a wide range of custom services. Our innovative & experienced technical staff acquired extensive know-how over the last 20 years of business in custom production and brings professional project management skills to fulfill your needs on time and to specification. Our brand new state-of-the-art laboratories guarantee production of your life science product at the highest level.
- Custom Assay development
- Custom Peptide Synthesis
- Custom Antibody Production
- Custom Protein Expression
- Custom Chemical Synthesis
- Custom-labeled FISH Probes